On the demanding necessity of properly evaluating renal graft function in clinical trials.

In order to directly address the potential dangers of estimating rather than measuring GFR in transplantation research protocols, we performed several simulations from a previously described cohort of 500 inulin clearances [5]. This cohort was split into two groups of n=250 each, either according to the date of transplantation (sorted by chronological order, simulation #1) or according to the recipient's age (sorted by increasing age, simulation #2).